Bioinformatic analysis and experimental verification reveal expansion of monocyte subsets with an interferon signature in systemic lupus erythematosus patients
Our study found that the expansion of IFN-I-producing monocyte subsets, particularly the CD14<sup>+</sup>SIGLEC1<sup>+</sup>IRF7<sup>+</sup> subset, plays a crucial role in SLE pathogenesis. This subset may serve as a potential biomarker and therapeutic target for managing SLE.
Authors
- Jingxiu Xuan (ORCID: https://orcid.org/0000-0002-4760-5096)
- Chaoqiong Deng
- Li Y (ORCID: https://orcid.org/0000-0003-1032-2292)
- Jimin Zhang
- Yuechi Sun (ORCID: https://orcid.org/0000-0001-6456-0363)
- Yan He (ORCID: https://orcid.org/0009-0001-6484-6537)
- Wenchen Zhuang
Institutions
- Xiamen University (CN)
- First Affiliated Hospital of Xiamen University (CN)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1186/s13075-025-03560-5
- Citations
- 6
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 10.01
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province