Feasibility study for proton dose calculation of esophageal squamous cell carcinoma based on stopping power ratio directly derived from dual energy CT
IMPT demonstrated superior OAR sparing compared to IMRT. For mid thoracic ESCC patients under proton therapy, dose calculations based on CT-HU conversion was showed comparable dosimetric impact to DECT-derived SPR in terms of target coverage and OAR protection. These findings support the clinical feasibility of conventional CT-based proton therapy planning and dose calculation.
Authors
- Mingming Nie (ORCID: https://orcid.org/0000-0003-3067-1588)
- Jinhu Chen (ORCID: https://orcid.org/0000-0002-4923-5076)
- Yuanyuan Yan (ORCID: https://orcid.org/0000-0003-0432-5518)
- Weijie Ye (ORCID: https://orcid.org/0009-0008-8136-4346)
- Xihuang Lin (ORCID: https://orcid.org/0000-0001-7250-0539)
- Yongbin Cui
- Miaomiao Li (ORCID: https://orcid.org/0000-0001-7678-687X)
- Yong Yin (ORCID: https://orcid.org/0000-0003-1090-4313)
- Yong Huang (ORCID: https://orcid.org/0000-0001-8095-4215)
- Qianyu Liu
Institutions
- Shandong University (CN)
- Philips (China) (CN)
- Shandong Tumor Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-04-23
- DOI
- https://doi.org/10.3389/fonc.2025.1591139
- Citations
- 1
- Primary Topic
- Advanced X-ray and CT Imaging
- Type
- article
- Field-Weighted Citation Impact
- 0.67
Funders
- National Natural Science Foundation of China