Effect of local radiofrequency hyperthermia on the intratumoral pressure and extracellular matrix stiffness in hepatocellular carcinoma
Local RFHT induces time- and heating profile-dependent alterations in intratumoral pressure and stiffness in a rat model of HCC, suggesting that RFHT interventions may modulate tumor biophysics and influence drug delivery.
Authors
- Rahul A. Sheth (ORCID: https://orcid.org/0000-0001-9615-8985)
- Anna Bottiglieri (ORCID: https://orcid.org/0009-0001-4732-274X)
- Amanda McWatters
- Punit Prakash (ORCID: https://orcid.org/0000-0001-6467-722X)
- Poonam Yadav (ORCID: https://orcid.org/0000-0002-0344-1261)
- Santosh Kumar Mandal (ORCID: https://orcid.org/0000-0002-7348-8217)
- Malea L. Williams
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Kansas State University (US)
- George Washington University (US)
Publication Details
- Journal
- International Journal of Hyperthermia
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1080/02656736.2025.2492766
- Citations
- 2
- Primary Topic
- Ultrasound and Hyperthermia Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- National Science Foundation
- Andrew Sabin Family Foundation
- Instituto Nacional de Cancerología