Long-term persistence of serum IgM antibodies against chikungunya virus in patients with chronic arthralgia
Our findings indicate that anti-CHIKV IgM antibodies can persist substantially longer than typically observed for acute RNA virus infections. This has significant implications for chikungunya diagnosis and surveillance. Further research is needed to determine whether long-term IgM persistence also occurs in patients without chronic chikungunya symptoms.
Authors
- Moyra Machado Portilho (ORCID: https://orcid.org/0000-0002-4316-4799)
- Scott C. Weaver (ORCID: https://orcid.org/0000-0001-8016-8556)
- Adriane Souza da Paz (ORCID: https://orcid.org/0000-0003-2199-1504)
- Rosângela O. Anjos (ORCID: https://orcid.org/0000-0003-3809-5335)
- Viviane M Cavalcanti
- Marcelo Cavenaghi Pereira da Silva (ORCID: https://orcid.org/0000-0002-3270-5086)
- Guilherme S. Ribeiro (ORCID: https://orcid.org/0000-0002-6798-2059)
- Uriel Kitron (ORCID: https://orcid.org/0000-0003-0493-2043)
- Moisés Simão Santa Rosa de Sousa (ORCID: https://orcid.org/0000-0002-0684-2079)
- Mittermayer Barreto Santiago (ORCID: https://orcid.org/0000-0003-1299-6389)
- Mitermayer Galvão dos Reis (ORCID: https://orcid.org/0000-0002-3051-9060)
- Patrícia S S Moreira
- Leile Camila Jacob-Nascimento (ORCID: https://orcid.org/0000-0002-1324-6187)
- Júlia Costa (ORCID: https://orcid.org/0000-0001-7782-6319)
- Lorena G Santos (ORCID: https://orcid.org/0000-0002-9374-9090)
Institutions
- Universidade Federal da Bahia (BR)
- Escola Bahiana de Medicina e Saúde Pública (BR)
- Emory University (US)
- Yale University (US)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- Virology Journal
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1186/s12985-025-02721-x
- Citations
- 4
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 7.51
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa do Estado da Bahia
- Ministério da Educação
- Ministério da Saúde
- Fundação Oswaldo Cruz