Dimethyl Pent-2-Enedioate inhibits LPS-induced inflammatory response in macrophages
DMP significantly inhibits LPS-induced inflammation in macrophages, with its underlying mechanisms being complex. Our data demonstrate that DMP exerts its anti-inflammatory effects at least in part through the downregulation of the NF-κB pathway, offering potential applications in the prevention and treatment of inflammation-related diseases.
Authors
- Zhanxiang Zhou
- Yuke Zhong
- Ying-Xing Yue (ORCID: https://orcid.org/0000-0003-0405-2804)
- Zhouxin Yang (ORCID: https://orcid.org/0000-0001-9559-2640)
- Zhipeng Zhou (ORCID: https://orcid.org/0000-0003-0775-8220)
- Guo-Long Cai (ORCID: https://orcid.org/0000-0001-7066-8637)
Institutions
- Wenzhou Medical University (CN)
- Zhejiang Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- University of Chinese Academy of Sciences (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Microbiology Immunology and Infection
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1016/j.jmii.2025.03.019
- Citations
- 1
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.80