Hydroxychloroquine increases the exposure of methotrexate in plasma and red blood cells: a pharmacokinetic interaction study in rats in vivo
These findings provide insights into the enhanced efficacy, faster onset, and prolonged effect of MTX-HCQ combination therapy compared to MTX monotherapy. The observed increases in MTX Cmax and AUC suggest the need for careful monitoring of MTX-related adverse effects, particularly in patients with renal insufficiency, during combination treatment with HCQ.
Authors
- G Chen
- Hongyu Jie (ORCID: https://orcid.org/0000-0002-6175-4055)
- Wen‐Ying Chen (ORCID: https://orcid.org/0000-0002-5105-5285)
- Guijie Zhang (ORCID: https://orcid.org/0000-0002-7847-5431)
- Qiang Li (ORCID: https://orcid.org/0000-0003-0731-5411)
- Rui Wang (ORCID: https://orcid.org/0000-0002-2404-7917)
- Simin Liu (ORCID: https://orcid.org/0000-0003-2098-3844)
Institutions
- Third Affiliated Hospital of Southern Medical University (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-24
- DOI
- https://doi.org/10.3389/fphar.2025.1561001
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 0.00