68Ga-FAPI and 18F-FAPI PET/CT for detection of nodal metastases prior radical cystectomy in high-risk urothelial carcinoma patients
Overall, FAPI PET imaging shows a significantly higher sensitivity than CT analysis for detection of locoregional lymph node metastases in UC. [<sup>18</sup>F]F-FAPI- 74 demonstrates a comparable diagnostic performance compared to [<sup>68</sup>Ga]Ga-FAPI- 46. Of note, the quantitative analysis with a pre-defined SUV<sub>max</sub> as well as SUV<sub>mean</sub> values, and SUV<sub>max_lymph node</sub>/SUV<sub>mean</sub>_<sub>background</sub> ratio-based cut-offs provided a higher sensitivity compared to visual assessment.
Authors
- Lena M. Unterrainer
- Gerald Bastian Schulz (ORCID: https://orcid.org/0000-0002-0340-0304)
- Alexander J. Tamalunas (ORCID: https://orcid.org/0000-0002-4659-2262)
- Lennert Eismann (ORCID: https://orcid.org/0000-0002-9971-4411)
- Stephan Ledderose (ORCID: https://orcid.org/0000-0001-7313-2088)
- Maximilian Scheifele
- Johannes Toms
- Adrien Holzgreve (ORCID: https://orcid.org/0000-0002-9566-8438)
- Jozefina Casuscelli (ORCID: https://orcid.org/0000-0002-9899-1986)
- Marcus Unterrainer (ORCID: https://orcid.org/0000-0002-8238-1198)
- Christian Georg Stief (ORCID: https://orcid.org/0000-0003-3291-9460)
- Stephan Tschirdewahn (ORCID: https://orcid.org/0000-0002-5600-468X)
- Alexander Karl (ORCID: https://orcid.org/0000-0003-2221-8038)
- Paula Menold
- Clemens C. Cyran (ORCID: https://orcid.org/0000-0001-5630-6242)
- Schmid Hp
- Sophie C. Kunte (ORCID: https://orcid.org/0009-0003-3175-952X)
Institutions
- Kempten University of Applied Sciences (DE)
- LMU Klinikum (DE)
- Ihre-Radiologen (DE)
- Krankenhaus Barmherzige Brüder (DE)
- Molecular Theranostics (United States) (US)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- European Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1007/s00259-025-07239-6
- Citations
- 5
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 5.23
Funders
- Ludwig-Maximilians-Universität München