Peroxidase-mimicking activities, photothermal, and antibiotic efficiency of silver selenide nanoparticles as an anti-methicillin-resistant <i>Staphylococcus aureus</i> agent
A new antibacterial mechanism developed by using multiple pathways is important to resolve the prevalence of antibiotic-resistant bacteria. This study shows the photothermal properties of Ag<sub>2</sub>Se nanoparticles under near-infrared (NIR) in a peroxidase-mimicking reaction. The photothermal conversion response is 47.85% under 808 nm NIR irradiation. Moreover, Ag<sub>2</sub>Se nanoparticles show the antibacterial activity by ineffective β-lactam antibiotic ceftazidime (CAZ) against methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) and increased membrane permeability of MRSA. Under synergistic conditions, Ag<sub>2</sub>Se killed 3.8 log<sub>10</sub> MRSA in the presence of NIR, CAZ, and H<sub>2</sub>O<sub>2</sub>, which is higher than Ag<sub>2</sub>Se + H<sub>2</sub>O<sub>2</sub> + NIR (3.4 log<sub>10</sub>) or Ag<sub>2</sub>Se + CAZ + NIR (2.9 log<sub>10</sub>). The hyperthermia generated by NIR irradiation, ROS from catalyzing H<sub>2</sub>O<sub>2</sub> and synergy with CAZ accounted showed the highest antibacterial influence of Ag<sub>2</sub>Se.
Authors
- B. Janani
- Mahmood Jasem Jawad (ORCID: https://orcid.org/0000-0001-6542-7230)
- Waam Mohammed Taher
- Leila Fatolahi
- Hiba Mushtaq
- Anmar Ghanim Taki
- Mariem Alwan
- Wadhah Hasan Alkhazali
Institutions
- Al Noor Hospitals (AE)
- Islamic Azad University of Farahan (IR)
- Ahl Al Bayt University (IQ)
- Palestine Ahliya University (PS)
- Al-Farahidi University
- Payame Noor University (IR)
Publication Details
- Journal
- International Journal of Environmental Health Research
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1080/09603123.2025.2497440
- Citations
- 1
- Primary Topic
- Advanced Nanomaterials in Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.52