Combinatorial biosynthesis of novel gentamicin derivatives with nonsense mutation readthrough activity and low cytotoxicity
These results demonstrate the potential of combinatorial biosynthesis to increase the diversity of structures of AGs and provide directions for the development of new AGs with low toxicity and high PTC readthrough activity.
Authors
- Huanzhang Xia (ORCID: https://orcid.org/0000-0003-1114-6833)
- Botong Liu
- Lihua Yang (ORCID: https://orcid.org/0000-0002-4660-9060)
- Xianpu Ni (ORCID: https://orcid.org/0000-0002-5666-3271)
- Tingting Tian
- Hang Zhai
Institutions
- Shenyang Pharmaceutical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-24
- DOI
- https://doi.org/10.3389/fphar.2025.1575840
- Citations
- 2
- Primary Topic
- Chemical Synthesis and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- Department of Education of Liaoning Province
- Scientific Research Fund of Liaoning Provincial Education Department