Attenuation of Atherosclerosis With PAR4 Deficiency: A Potential Role of Hematopoietically Expressed PAR4 in Atherosclerosis—Brief Report
We conclude that hematopoietic-derived PAR4 plays a vital role in the development and progression of atherosclerosis. More specifically, we observe thrombin-activated PAR4 contributes to the progression. Specifically, targeting of PAR4 may be a potential therapeutic target for cardiovascular disease.
Authors
- Anthony Spuzzillo (ORCID: https://orcid.org/0000-0002-6568-8999)
- Deborah A. Howatt (ORCID: https://orcid.org/0000-0002-0078-092X)
- Albert Phillip Owens (ORCID: https://orcid.org/0000-0002-0835-620X)
- Joel Thompson (ORCID: https://orcid.org/0000-0002-9609-7606)
- Caris Wadding-Lee (ORCID: https://orcid.org/0000-0002-8194-8543)
- Nigel Mackman (ORCID: https://orcid.org/0000-0002-9170-7700)
- Alan Daugherty (ORCID: https://orcid.org/0000-0003-2093-3775)
- Stuart Shearer
- Benjamin E. Tourdot (ORCID: https://orcid.org/0000-0002-1701-4041)
- Tyler W. Benson
- Megan Jay
Institutions
- University of North Carolina at Chapel Hill (US)
- Cincinnati Children's Hospital Medical Center (US)
- University of North Carolina Health Care (US)
- University of Kentucky (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1161/atvbaha.124.322068
- Citations
- 2
- Primary Topic
- Blood Coagulation and Thrombosis Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.54