Chemical constituents from <i>symplocos sumuntia</i> and their anti-inflammatory effect

<i>Symplocos sumuntia</i> Buch-Ham ex D Don is traditionally used to relieve inflammation in Vietnam. This study described a chemical investigation that led to isolation and identification of one new and nine known compounds. Their structures were determined by using spectroscopic techniques. Compounds <b>1 </b>-<b> 10</b> possessed inhibitory activities on NO production induced by LPS activated macrophages. Among them, compounds <b>2</b> and <b>3</b> demonstrated strong ability to reduce NO production with IC₅₀ values of 3.91 ± 0.05 and 3.96 ± 0.24 µM, respectively. Some of the other compounds also reduced NO production in LPS stimulated RAW264.7 cells. <i>In-silico</i> study supported hints to the bioactivity of compounds <b>2</b> and <b>3</b> by analysing the interactions of those when they were docked with protein to create complexes targeting anti-inflammation. Our research revealed the chemical components of this plant and its active ingredients that target inflammation, highlighting its therapeutic potential to improve its value for traditional uses.