Risk factors for influenza virus infection in patients with hematological disease

Influenza virus infections (IVIs) are an important cause of complications and death in immunocompromised patients, but the incidence and risk factors for IVIs in hematological diseases including benign diseases are not fully understood. We retrospectively investigated IVIs in patients with hematological diseases who visited our hematology outpatient department between 2012 and 2019. In 4,864 outpatients, 81(1.67%) IVIs were identified. The incidence of IVIs was 4.82 (95% confidence interval [CI], 3.85-5.96) per 1,000 person-years, with significantly higher rates in post-allogeneic transplant patients (21.0, 95% CI, 12.8-32.5). Progression to lower respiratory tract infection (LRTI) was observed in 7 (8.6%) of 81 patients with IVIs. In a univariate logistic regression analysis, LTRI was associated with age ≥60 years and moderate to severe chronic GVHD. Patients after hematopoietic stem cell transplantation may be at a higher risk for IVIs. Advanced age exacerbated the effects of IVIs on hematological diseases.

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Publication Details

Journal
Leukemia & lymphoma/Leukemia and lymphoma
Published
2025-04-24
DOI
https://doi.org/10.1080/10428194.2025.2495106
Citations
1
Primary Topic
Respiratory viral infections research
Type
article
Field-Weighted Citation Impact
1.35
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article

Risk factors for influenza virus infection in patients with hematological disease

Kazuki Hyodo, Yoshinobu Kanda, Ken Ohmine, Hirotomo Nakashima et al.
1 citations
Leukemia & lymphoma/Leukemia and lymphoma
Respiratory viral infections research
1.35
article

Risk factors for influenza virus infection in patients with hematological disease

Kazuki Hyodo, Yoshinobu Kanda, Ken Ohmine, Hirotomo Nakashima, Rui Murahashi, Shunsuke Koyama, Sumihisa Honda, Yumiko Toda, Ryutaro Tominaga, Atsuto Noguchi, Daizo Yokoyama, Shuka Furuki, Kento Umino, Daisuke Minakata, Kaoru Hatano, Takashi Ikeda, Chihiro Yamamoto, Shin‐ichiro Kawaguchi, Kazuya Sato, Shin-ichiro Fujiwara, Masahiro Ashizawa
article en
1 citations

Abstract

Influenza virus infections (IVIs) are an important cause of complications and death in immunocompromised patients, but the incidence and risk factors for IVIs in hematological diseases including benign diseases are not fully understood. We retrospectively investigated IVIs in patients with hematological diseases who visited our hematology outpatient department between 2012 and 2019. In 4,864 outpatients, 81(1.67%) IVIs were identified. The incidence of IVIs was 4.82 (95% confidence interval [CI], 3.85-5.96) per 1,000 person-years, with significantly higher rates in post-allogeneic transplant patients (21.0, 95% CI, 12.8-32.5). Progression to lower respiratory tract infection (LRTI) was observed in 7 (8.6%) of 81 patients with IVIs. In a univariate logistic regression analysis, LTRI was associated with age ≥60 years and moderate to severe chronic GVHD. Patients after hematopoietic stem cell transplantation may be at a higher risk for IVIs. Advanced age exacerbated the effects of IVIs on hematological diseases.

Leukemia & lymphoma/Leukemia and lymphomaVol. 66(9)
Jichi Medical University (JP), Jichi Medical University Hospital (JP), Jichi Medical University Saitama Medical Center (JP)
Good health and well-being
Openalex Percentile: Top 21%
Respiratory viral infections research
1.35
DOISourceOpenAlex
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