Beneficial effect of infiltration around the greater occipital nerve in cluster headache independent of modulation of the nociceptive blink reflex
The observed neurophysiological alterations were minor and were not associated with any clinical outcome. Therefore, despite rigorous analysis of multiple neurophysiological parameters in a relatively large patient sample, we did not find any evidence that the clinical response of GON infiltration is caused by reduced-or modulated-transmission of the trigeminal nerve or the trigeminal cervical complex. Although effective, the mechanism of the GON infiltration thus remains enigmatic.
Authors
- Martijn R. Tannemaat (ORCID: https://orcid.org/0000-0003-2929-0390)
- Marieke Hellinga
- Roemer B. Brandt (ORCID: https://orcid.org/0000-0002-2932-4872)
- Willemijn C. Naber (ORCID: https://orcid.org/0000-0002-9260-9336)
- Rolf Fronczek (ORCID: https://orcid.org/0000-0002-1935-7603)
- Marieke Niesters (ORCID: https://orcid.org/0009-0002-2822-7509)
- Paulien J. van Tilborg (ORCID: https://orcid.org/0009-0001-9233-0538)
Institutions
- Leiden University Medical Center (NL)
Publication Details
- Journal
- Headache The Journal of Head and Face Pain
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1111/head.14946
- Citations
- 1
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Eli Lilly and Company
- Teva Pharmaceutical Industries
- Universiteit Leiden
- Hersenstichting
- H. Lundbeck A/S