Supramolecular Nanoplatforms with Activable Ultrasound and Magnetic Resonance Imaging for Cancer Diagnosis and Therapy

Excellent multifunctional platforms for cancer diagnosis and treatment are highly desirable. Herein, multifunctional nanocomposites are constructed by utilizing Mn²⁺ to coordinate to the imidazole moiety anchored on CuO₂ nanoparticles through cyclodextrin-adamantane interaction. The encapsulated CuO₂ nanoparticles (NPs) can generate hydrogen peroxide (H₂O₂) at tumor sites under acidic conditions upon decomposition, which is further turned into oxygen (O₂) under Mn²⁺ catalysis, facilitating both ultrasound and magnetic resonance imaging (MRI). Moreover, the proposed nanomedicine enhances reactive oxygen species (ROS) generation and depletes glutathione (GSH), leading to increased lipid peroxidation (LPO) and effective ferroptosis-mediated cancer therapy. Such a strategy presents a promising approach for the development of theranostics for imaging-guided tumor therapy.