Brucellosis: An overlooked cause of pyrexia of unknown origin in a child

Paediatric brucellosis can be asymptomatic or present as an acute, persistent febrile illness. Limited literature on this disease in the paediatric population often leads to delayed diagnoses or undiagnosed cases. A previously healthy 10-year-old boy presented with a 2-month history of fever and a weight loss of 2 kg. On examination, hepatosplenomegaly was noted. His haemogram showed anaemia and leucopenia. Blood culture identified Brucella melitensis , which was sensitive to doxycycline and rifampicin. The Brucella agglutination test further confirmed the diagnosis. He was successfully treated with oral doxycycline and rifampicin. This case highlights the importance of considering brucellosis in the differential diagnosis of children with pyrexia of unknown origin.

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Publication Details

Journal
Karnataka Pediatric Journal
Published
2025-04-24
DOI
https://doi.org/10.25259/kpj_8_2025
Primary Topic
Brucella: diagnosis, epidemiology, treatment
Type
article
Field-Weighted Citation Impact
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article

Brucellosis: An overlooked cause of pyrexia of unknown origin in a child

Jay Naik, Thirunavukkarasu Arun Babu
Karnataka Pediatric Journal
Brucella: diagnosis, epidemiology, treatment
article

Brucellosis: An overlooked cause of pyrexia of unknown origin in a child

Jay Naik, Thirunavukkarasu Arun Babu
article en

Abstract

Paediatric brucellosis can be asymptomatic or present as an acute, persistent febrile illness. Limited literature on this disease in the paediatric population often leads to delayed diagnoses or undiagnosed cases. A previously healthy 10-year-old boy presented with a 2-month history of fever and a weight loss of 2 kg. On examination, hepatosplenomegaly was noted. His haemogram showed anaemia and leucopenia. Blood culture identified Brucella melitensis , which was sensitive to doxycycline and rifampicin. The Brucella agglutination test further confirmed the diagnosis. He was successfully treated with oral doxycycline and rifampicin. This case highlights the importance of considering brucellosis in the differential diagnosis of children with pyrexia of unknown origin.

Karnataka Pediatric JournalVol. 40
All India Institute of Medical Sciences Raipur (IN), All India Institute of Medical Sciences Bhopal (IN), All India Institute of Medical Sciences (IN)
Openalex Percentile: Top 90%
Brucella: diagnosis, epidemiology, treatment
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