IGF2BP2-mediated m6A modifies SLC7A11 to regulate proliferation and ferroptosis in non-small cell lung cancer cells
IGF2BP2 plays a critical role in NSCLC by stabilizing SLC7A11 mRNA via m6A modification, promoting cell proliferation and suppressing ferroptosis. Targeting the IGF2BP2-SLC7A11 axis may offer a promising therapeutic strategy for NSCLC.
Authors
- Bo Li (ORCID: https://orcid.org/0000-0002-7979-8339)
- Yichao Yan (ORCID: https://orcid.org/0000-0001-7889-6394)
- Siying Li (ORCID: https://orcid.org/0000-0001-6906-8394)
Institutions
- Peking University (CN)
- Yingkou Institute of Technology (CN)
- Peking University International Hospital (CN)
Publication Details
- Journal
- Advances in Clinical and Experimental Medicine
- Published
- 2025-04-24
- DOI
- https://doi.org/10.17219/acem/200588
- Citations
- 2
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.61