Variability in Meropenem Distribution and Clearance in Children with Sepsis: Population-Based Pharmacokinetics with Assessment of Renal Biomarkers
Wide variation in meropenem concentrations in children with sepsis as compared to those without sepsis prompt close monitoring of GFR and drug concentrations in this population.
Authors
- Julie Huynh (ORCID: https://orcid.org/0000-0001-8341-496X)
- John S. Bradley (ORCID: https://orcid.org/0000-0002-3835-5064)
- Erin K. Bradley (ORCID: https://orcid.org/0000-0001-5801-9407)
- Edmund V. Capparelli (ORCID: https://orcid.org/0000-0002-1630-0505)
- Sean N. Avedissian (ORCID: https://orcid.org/0000-0002-0935-6455)
- Jeremiah D. Momper (ORCID: https://orcid.org/0000-0002-3154-6685)
- Jennifer Lê (ORCID: https://orcid.org/0000-0002-6692-0884)
- Amy M. Sitapati (ORCID: https://orcid.org/0000-0002-5737-5925)
- Robert H. Mak (ORCID: https://orcid.org/0000-0002-8512-9000)
- Annie Mai
- Karandeep Singh (ORCID: https://orcid.org/0000-0001-6030-1663)
- Helen Harvey (ORCID: https://orcid.org/0000-0001-5835-9575)
- Brandon Vo
Institutions
- University of California, Riverside (US)
- University of Nebraska at Omaha (US)
- University of California San Diego (US)
- Rady Children's Hospital-San Diego (US)
- University of Nebraska Medical Center (US)
- University of Montana (US)
Publication Details
- Journal
- Clinical Pharmacokinetics
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1007/s40262-025-01495-3
- Citations
- 1
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development