Formation of Mixed‐Valence Cage‐Like Polyoxidovanadates at 37°C Upon Reaction of V<sup>IV</sup>O(acetylacetonato)<sub>2</sub> With Lysozyme
Crystals of the model protein lysozyme were grown and soaked with the potential drug V<sup>IV</sup>O(acetylacetonato)<sub>2</sub> at 37°C. X-ray diffraction and electron paramagnetic resonance (EPR) data collected at this temperature reveal that mixed-valence cage-like polyoxidovanadate clusters are formed and covalently bind protein residue side chains at physiological temperature.
Authors
- Giarita Ferraro (ORCID: https://orcid.org/0000-0001-9385-2429)
- Antonello Merlino (ORCID: https://orcid.org/0000-0002-1045-7720)
- Gabriella Tito (ORCID: https://orcid.org/0000-0001-5682-3100)
Institutions
- University of Sassari (IT)
- Istituto Nazionale di Fisica Nucleare, Sezione di Napoli (IT)
- University of Naples Federico II (IT)
Publication Details
- Journal
- Chemistry - A European Journal
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1002/chem.202500488
- Citations
- 10
- Primary Topic
- Vanadium and Halogenation Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 5.37
Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca