Specific quantification of intact lipid nanocapsules in rats using FRET: biodistribution and PBPK model development
This study presents the first biodistribution analysis of intact LNC using a validated quantification method, enabling the development of a PBPK model that improves the understanding of nanoparticle PK mechanisms.
Authors
- Florence Gattacceca (ORCID: https://orcid.org/0000-0002-4944-8063)
- Grégory Hilairet
- Norraseth Kaeokhamloed (ORCID: https://orcid.org/0000-0002-1324-1554)
- Emilie Roger (ORCID: https://orcid.org/0000-0002-1183-1745)
- Samuel Legeay (ORCID: https://orcid.org/0000-0001-5393-995X)
- Vincent Lebreton (ORCID: https://orcid.org/0000-0001-5719-3796)
- Jessica Ou
- Rana Elfatairi
- Jérôme Bejaud
- Mariam Mahdjoub
Institutions
- Institut national de recherche en sciences et technologies du numérique (FR)
- Inserm (FR)
- Institut Universitaire de France (FR)
- Aix-Marseille Université (FR)
- Cancer Research Center (US)
- Université d'Angers (FR)
Publication Details
- Journal
- Nanomedicine
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1080/17435889.2025.2492537
- Citations
- 1
- Primary Topic
- Protein Interaction Studies and Fluorescence Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Ligue Contre le Cancer
- Erasmus+