Drug Side Effects Prediction by Using ML And NLP

Adverse drug side effects pose significant challenges in pharmaceutical research, ranking as a leading cause of treatment failure and mortality.Traditional laboratory-based evaluations of drug side effects are resource-intensive and time-consuming, necessitating the adoption of machine learning techniques for efficient and accurate predictions.This study explores the use of supervised learning approaches for drug side effect prediction, leveraging biomedical data and computational models.We employ various feature extraction techniques, including Bag of Words (BOW) and Term Frequency-Inverse Document Frequency (TF-IDF), combined with classification models such as Logistic Regression, Random Forest, and Support Vector Machines (SVM).Experimental results demonstrate that the TF-IDF-based models achieve superior performance, with Logistic Regression attaining a test accuracy of 80.88% and SVM achieving 80.90%.These findings highlight the potential of machine learning in predicting drug side effects, optimizing drug safety assessments, and reducing the risks associated with adverse reactions.Our study provides a comprehensive analysis of model effectiveness and discusses key challenges, research gaps, and future directions for improving predictive performance in this critical domain.

Publication Details

Journal
IARJSET
Published
2025-04-23
DOI
https://doi.org/10.17148/iarjset.2025.12427
Primary Topic
Pharmacovigilance and Adverse Drug Reactions
Type
article
Field-Weighted Citation Impact
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article

Drug Side Effects Prediction by Using ML And NLP

IARJSET
Pharmacovigilance and Adverse Drug Reactions
article

Drug Side Effects Prediction by Using ML And NLP

article en

Abstract

Adverse drug side effects pose significant challenges in pharmaceutical research, ranking as a leading cause of treatment failure and mortality.Traditional laboratory-based evaluations of drug side effects are resource-intensive and time-consuming, necessitating the adoption of machine learning techniques for efficient and accurate predictions.This study explores the use of supervised learning approaches for drug side effect prediction, leveraging biomedical data and computational models.We employ various feature extraction techniques, including Bag of Words (BOW) and Term Frequency-Inverse Document Frequency (TF-IDF), combined with classification models such as Logistic Regression, Random Forest, and Support Vector Machines (SVM).Experimental results demonstrate that the TF-IDF-based models achieve superior performance, with Logistic Regression attaining a test accuracy of 80.88% and SVM achieving 80.90%.These findings highlight the potential of machine learning in predicting drug side effects, optimizing drug safety assessments, and reducing the risks associated with adverse reactions.Our study provides a comprehensive analysis of model effectiveness and discusses key challenges, research gaps, and future directions for improving predictive performance in this critical domain.

IARJSETVol. 12(4)
Openalex Percentile: Top 92%
Pharmacovigilance and Adverse Drug Reactions
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Drug Side Effects Prediction by Using ML And NLP · IARJSET (2025) | TGRS Research Map | TGRS