Proteomics approach identifies aqueous humor biomarkers in retinal diseases
Our integrative analysis demonstrates a robust framework for AH biomarker discovery and identifies SMOC2 and IL-6 as promising biomarkers for GA. Our findings underscore the potential of AH proteomic profiling to advance our understanding of the underlying pathophysiology of retinal diseases.
Authors
- Kevin Huang (ORCID: https://orcid.org/0009-0008-6943-4970)
- Lee Honigberg (ORCID: https://orcid.org/0000-0003-0996-1062)
- Vincent Wolowski
- Juliane Siebourg‐Polster (ORCID: https://orcid.org/0000-0002-1759-3223)
- Andreas Dieckmann
- Vahan B. Indjeian (ORCID: https://orcid.org/0000-0002-9393-0017)
- Trung Nguy (ORCID: https://orcid.org/0000-0002-0171-2873)
- Justus G. Garweg (ORCID: https://orcid.org/0000-0003-3973-5082)
- Jason A. Hackney (ORCID: https://orcid.org/0000-0002-5922-563X)
- Randall Dere (ORCID: https://orcid.org/0000-0003-4120-7828)
- Michael Chang (ORCID: https://orcid.org/0000-0003-3063-6723)
- CJ Schofield
Institutions
- Roche (Switzerland) (CH)
- University of Bern (CH)
- University Hospital of Bern (CH)
- Gene Therapy Laboratory (FR)
- Berner Augenklinik am Lindenhofspital (CH)
- Bioanalytica (Switzerland) (CH)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1038/s43856-025-00862-2
- Citations
- 9
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 15.36