A practical approach to handling missing sputum samples in airway disease research
Imputation increases statistical power and addresses rather than ignores missing data. We suggest that sputum-based outcome measures should be reported using both complete case analyses and with missing data imputed with the choice of imputation method decided based on study design, consequences of over- and under-estimation and ability to address bias.
Authors
- Asger Sverrild (ORCID: https://orcid.org/0000-0003-0625-6405)
- Laurits Frøssing (ORCID: https://orcid.org/0000-0001-8488-3741)
- Morten Hvidtfeldt (ORCID: https://orcid.org/0000-0002-7995-2965)
- Susanne Hansen (ORCID: https://orcid.org/0000-0002-9550-6703)
- Celeste Porsbjerg (ORCID: https://orcid.org/0000-0003-4825-9436)
Institutions
- University of Copenhagen (DK)
- Frederiksberg Hospital (DK)
- Bispebjerg Hospital (DK)
- Center for Clinical Research and Prevention (DK)
Publication Details
- Journal
- ERJ Open Research
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1183/23120541.00043-2025
- Citations
- 2
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.33