Olaparib as a rescue treatment in platinum-refractory germ-cell tumors: the IGG-02 phase II trial
Olaparib as a single agent demonstrated no activity in heavily pretreated GCT patients. Future studies with PARP inhibitors should be planned in less-pretreated GCT patients based on molecular analysis to support better patient selection.
Authors
- Ilaria De Santis (ORCID: https://orcid.org/0000-0002-0240-7571)
- Marilena Di Napoli (ORCID: https://orcid.org/0000-0003-4516-7341)
- Valentina Zampiga (ORCID: https://orcid.org/0000-0002-7356-8153)
- Anna Miserocchi
- Jole Ventriglia (ORCID: https://orcid.org/0000-0002-8160-5014)
- Milena Urbini (ORCID: https://orcid.org/0000-0002-3364-9098)
- Elisabetta Petracci (ORCID: https://orcid.org/0000-0001-9456-3514)
- Cristian Lolli (ORCID: https://orcid.org/0000-0003-0347-9179)
- G. Schepisi
- Sabrina Chiara Cecere (ORCID: https://orcid.org/0000-0002-7915-1623)
- Ilaria Cangini (ORCID: https://orcid.org/0000-0002-1739-6916)
- Sabrina Rossetti (ORCID: https://orcid.org/0000-0002-9337-5885)
- Giorgia Gurioli (ORCID: https://orcid.org/0000-0003-4036-5568)
- Cecilia Menna (ORCID: https://orcid.org/0000-0002-9154-6919)
- Ugo De Giorgi (ORCID: https://orcid.org/0000-0001-7520-2908)
- Umberto Basso (ORCID: https://orcid.org/0000-0002-5075-2177)
- Sandro Pignata (ORCID: https://orcid.org/0000-0002-8836-2633)
- Chiara Casadei (ORCID: https://orcid.org/0000-0003-2467-749X)
- Greta Mambelli
- V. Gallà
Institutions
- Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IT)
- Istituto Oncologico Veneto (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1016/j.esmoop.2025.105056
- Citations
- 4
- Primary Topic
- PARP inhibition in cancer therapy
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- Ministero della Salute