Tumor-informed ctDNA assay to predict recurrence in locally advanced squamous-cell carcinoma of the head and neck (SCCHN)
The personalized, tumor-informed assay detected pre-treatment ctDNA in the majority of the patients with LA SCCHN. ctDNA positivity within 12 weeks of completing curative-intent treatment was predictive of worse RFS and OS. These results support studies to assess the value of longitudinal testing for surveillance and may open the path to initiating treatment upon molecular recurrence in patients with LA SCCHN.
Authors
- Vasily N. Aushev (ORCID: https://orcid.org/0000-0001-8003-358X)
- J-P. Machiels
- С. А. Величко
- George Laliotis (ORCID: https://orcid.org/0000-0001-9205-8258)
- Hajar Dahou (ORCID: https://orcid.org/0009-0001-4479-5760)
- Natasha Honoré (ORCID: https://orcid.org/0009-0007-0684-9143)
- Charuta C. Palsuledesai (ORCID: https://orcid.org/0000-0002-3850-260X)
- Rachel Galot (ORCID: https://orcid.org/0000-0002-0596-4752)
- Cédric van Marcke (ORCID: https://orcid.org/0000-0003-3454-0630)
- Min Liu (ORCID: https://orcid.org/0000-0002-1918-9072)
Institutions
- Cliniques Universitaires Saint-Luc (BE)
- Natera (United States) (US)
- UCLouvain (BE)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1016/j.esmoop.2025.104534
- Citations
- 7
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 6.55