Lung disease in never-smokers with severe α <sub>1</sub> -antitrypsin deficiency: the EARCO Registry
Among PI*ZZ never-smokers lung disease remains prevalent, even if milder. Nonetheless, some never-smokers develop severe lung impairment requiring augmentation therapy. Non-index cases are healthier with a higher quality of life. Among never-smokers, lower body mass index, male sex, comorbidities and pulmonary exacerbations are associated with fixed airflow obstruction.
Authors
- Carlota Rodríguez‐García
- Francesco Blasi (ORCID: https://orcid.org/0000-0002-2285-9970)
- Míriam Barrecheguren (ORCID: https://orcid.org/0000-0002-6041-1499)
- María Torres‐Durán (ORCID: https://orcid.org/0000-0001-6710-3766)
- Marco Mantero (ORCID: https://orcid.org/0000-0001-7324-1217)
- Hanan A. Tanash (ORCID: https://orcid.org/0000-0002-0913-2347)
- Cristina Aljama (ORCID: https://orcid.org/0000-0002-6151-4174)
- Angelo Guido Corsico (ORCID: https://orcid.org/0000-0002-8716-4694)
- Jens‐Ulrik Stæhr Jensen (ORCID: https://orcid.org/0000-0003-4036-0521)
- Cristina Esquinas
- Ilaria Ferrarotti (ORCID: https://orcid.org/0000-0003-4892-4192)
- Alice Margaret Turner (ORCID: https://orcid.org/0000-0002-5947-3254)
- Marc Miravitlles (ORCID: https://orcid.org/0000-0002-9850-9520)
- Galo Granados (ORCID: https://orcid.org/0000-0002-1902-1835)
- Chiara Premuda (ORCID: https://orcid.org/0009-0007-7619-8913)
Institutions
- University of Copenhagen (DK)
- University Hospitals Birmingham NHS Foundation Trust (GB)
- Lund University (SE)
- University of Milan (IT)
- University Hospital Complex Of Vigo (ES)
- Gentofte Hospital (DK)
- Foundation Center (US)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Complejo Hospitalario Universitario de Santiago (ES)
- Vall d'Hebron Institut de Recerca (ES)
- Zero to Three (US)
- Skåne University Hospital (SE)
- Policlinico San Matteo Fondazione (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- ERJ Open Research
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1183/23120541.01279-2024
- Primary Topic
- Protease and Inhibitor Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- CSL Behring
- Takeda Pharmaceutical Company
- European Respiratory Society
- National Institute for Health and Care Research
- Department of Health and Social Care
- Sociedad Española de Neumología y Cirugía Torácica
- Grifols