Genome‐wide <scp>DNA</scp> methylation profiles in the raphe nuclei of patients with autism spectrum disorder
Our findings reveal extensive DNA methylation changes in critical genomic regions, shedding light on potential mechanisms underlying ASD. The identification of RABGGTB as a novel candidate gene, not listed in the SFARI database, underscores its significance and warrants further research to explore its role in ASD diagnosis. This study enhances our understanding of the epigenetic landscape in ASD, emphasizing the interplay between genetic and environmental factors in its pathophysiology.
Authors
- Kazuhiko Nakamura (ORCID: https://orcid.org/0000-0001-7375-5867)
- Keisuke Ishiwata (ORCID: https://orcid.org/0000-0002-1444-3035)
- Kazuhiko Nakabayashi (ORCID: https://orcid.org/0000-0003-2927-0963)
- Yosuke Kameno (ORCID: https://orcid.org/0000-0002-5164-5963)
- Hideo Matsuzaki (ORCID: https://orcid.org/0000-0002-6869-1261)
- Keiko Iwata (ORCID: https://orcid.org/0000-0001-9588-3106)
- Ken‐ichiro Hata
Institutions
- Kanazawa University (JP)
- University of Fukui (JP)
- Hirosaki University (JP)
- Chiba University (JP)
- Gunma University (JP)
- Wakayama Medical University (JP)
- Hamamatsu University School of Medicine (JP)
- National Center For Child Health and Development (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Psychiatry and Clinical Neurosciences
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1111/pcn.13830
- Citations
- 2
- Primary Topic
- Autism Spectrum Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 2.86
Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Society for the Promotion of Science