Effect of bee venom (Apis mellifera) on liver damage in mice with Ehrlich ascites carcinoma

Cancer is a terrible illness that has enormously detrimental effects on society, the economy, health care and personal lives. In 2012, there were around 14.1 million cancer cases diagnosed worldwide, with 52.5% of those instances occurring in men and 47.5% in women. By 2030, that number is predicted to increase to 21.7 million. In 2012, this illness was responsible for 8.2 million fatalities globally; by the end of 2030, that number is predicted to rise to 13.0 million. The purpose of our study was to evaluate the capability of Apis mellifera venom (A.M.) to reduce renal toxicity and tissue damage caused by Ehrlich ascites carcinoma (EAC) in mice. A total of forty female Swiss albino mice were divided evenly among four groups (G1, control, G2, A.M., G3, EAC, and G4, EAC + A.M.). The findings demonstrated that, in comparison to the EAC group, the addition of Apis mellifera venom in co-treated groups resulted in lower levels of alpha-fetoprotein (AFP), ANA, anti-dsDNA, AST, ALT, and ALP. Liver slices from EAC showed several histological alterations, including mild fibrosis, noticeable diffuse necrosis of the hepatic parenchyma, noticeable inflammatory cells, and clogged blood sinusoids. Conversely, liver sections of mice co-treated with EAC+Apis mellifera showed a modest improvement in hepatocytes.