Nanomotion technology for testing azithromycin susceptibility of <i>Salmonella enterica</i>
Azithromycin is used as a last-resort antibiotic to treat life-threatening infections caused by <i>Salmonella enterica</i>, a high-priority pathogen according to the World Health Organization. Resistance levels to azithromycin are increasing, highlighting the need for rapid susceptibility testing. In this study, we demonstrate that nanomotion technology can detect azithromycin susceptibility in <i>Salmonella</i>, suggesting its potential use for rapid resistance detection in clinical settings and its future use with azithromycin. Additionally, the study shows that nanomotion technology can be used for susceptibility and postantibiotic effect testing for various pathogens and antibacterials, including those generally regarded as bacteriostatic.
Authors
- Alexander Sturm (ORCID: https://orcid.org/0000-0002-3818-0428)
- Tanel Tenson (ORCID: https://orcid.org/0000-0002-0260-3601)
- Tailise de Souza Guerreiro Rodrigues
- Christèle Aubry
- Mariliis Hinnu (ORCID: https://orcid.org/0000-0002-6096-0658)
- Danuta Cichocka (ORCID: https://orcid.org/0000-0002-1616-331X)
- Niilo Kaldalu (ORCID: https://orcid.org/0000-0002-1457-2291)
- Susanne Häußler (ORCID: https://orcid.org/0000-0001-6141-9102)
- Stefano Pagliara (ORCID: https://orcid.org/0000-0002-9025-4658)
- Toomas Mets (ORCID: https://orcid.org/0000-0002-6796-7000)
- Rafael Cantón (ORCID: https://orcid.org/0000-0003-1675-3173)
- Ivana Kerkez
- Marta Pla Verge (ORCID: https://orcid.org/0000-0002-9811-5361)
- Gilbert Greub (ORCID: https://orcid.org/0000-0001-9529-3317)
- Marta Putrinš (ORCID: https://orcid.org/0000-0003-1492-2826)
- Gino Cathomen (ORCID: https://orcid.org/0009-0006-1362-3399)
- Amanda Luraschi-Eggemann
- María García-Castillo (ORCID: https://orcid.org/0000-0001-7694-4006)
- Maria Georgevia
- Nicolas Oswaldo Trinler
Institutions
- University of Exeter (GB)
- Centro de Investigación Biomédica en Red (ES)
- Helmholtz Centre for Infection Research (DE)
- Instituto Ramón y Cajal de Investigación Sanitaria (ES)
- Living Systems (United States) (US)
- University of Tartu (EE)
- University of Lausanne (CH)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1128/spectrum.02385-24
- Citations
- 4
- Primary Topic
- Vibrio bacteria research studies
- Type
- article
- Field-Weighted Citation Impact
- 7.19
Funders
- European Commission
- Eesti Teadusagentuur