Nano-zinc oxide (nZnO) targets the AMPK-ULK1 pathway to promote bone regeneration
These results highlight that nZnO can regulate bone regeneration by activating autophagy through the AMPK/ULK1 signaling pathway, which may provide a novel therapeutic strategy for addressing bone defects using nZnO.
Authors
- Aihua Gu (ORCID: https://orcid.org/0000-0001-7576-9998)
- May D. Wang (ORCID: https://orcid.org/0000-0003-3961-3608)
- Zhenkun Weng
- Qing Yan (ORCID: https://orcid.org/0000-0002-7357-1053)
- Jingjia Liang
- Hongchao Zhang (ORCID: https://orcid.org/0000-0003-2716-3267)
- Qian Liu (ORCID: https://orcid.org/0000-0002-1937-0568)
- Jin Xu (ORCID: https://orcid.org/0000-0002-6287-5633)
- Xiu Chen (ORCID: https://orcid.org/0000-0002-1686-6269)
- Jian Jiao (ORCID: https://orcid.org/0000-0002-6291-820X)
Institutions
- Nanjing Children's Hospital (CN)
- Ministry of Education (KR)
- Shanghai East Hospital (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Changzhou No.2 People's Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1186/s13287-025-04322-5
- Citations
- 4
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- National Science Foundation
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province