Sarcosine sensitizes lung adenocarcinoma to chemotherapy by dual activation of ferroptosis via PDK4/PDHA1 signaling and NMDAR-mediated iron export
Sarcosine promotes ferroptosis and enhances chemosensitivity, suggesting its potential as a therapeutic agent in treating LUAD.
Authors
- Guangyao Shan (ORCID: https://orcid.org/0000-0002-2993-5817)
- Guoshu Bi (ORCID: https://orcid.org/0000-0003-2187-5271)
- Yunyi Bian (ORCID: https://orcid.org/0000-0003-3864-1199)
- Hong Fan (ORCID: https://orcid.org/0000-0002-2005-1150)
- Zhengyang Hu (ORCID: https://orcid.org/0000-0003-4541-1826)
- Dejun Zeng
- Guangyu Yao (ORCID: https://orcid.org/0000-0001-7389-0401)
- Cheng Zhan (ORCID: https://orcid.org/0000-0001-8745-9276)
- Shencheng Ren
- Zhaolin Zheng
- Binyang Pan
Institutions
- Zhongshan Hospital of Xiamen University (CN)
- Zhongshan Hospital (CN)
Publication Details
- Journal
- Experimental Hematology and Oncology
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1186/s40164-025-00657-0
- Citations
- 6
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 9.11
Funders
- National Natural Science Foundation of China