PD-L1 and ICAM1 over expression empowers immunoregulation of mesenchymal stromal cells to improve the autoimmune hepatitis treatment efficacy
PD-L1 and ICAM1 empower MSCs immuno-regulation, these empowered MSCs are more effective treatment for AIH. These findings provide support for the translation of PI-MSCs to the clinic for treatment of AIH patients.
Authors
- Congge Li
- Tianqing Li
- Sili Wei
- Huili Gou
- Xiaofan Ge
- Hongzhi Cai
- Liting Yang (ORCID: https://orcid.org/0009-0004-7562-6590)
- Caie Qiu
- X. J. Bai
- Wei Yang (ORCID: https://orcid.org/0009-0005-8713-6262)
- Tingting Liu (ORCID: https://orcid.org/0000-0002-3591-9266)
Institutions
- Kunming University of Science and Technology (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1186/s13287-025-04347-w
- Citations
- 2
- Primary Topic
- Liver Diseases and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 2.64
Funders
- Natural Science Foundation of Yunnan Province
- Key Technologies Research and Development Program
- National Key Research and Development Program of China