Dietary Nucleotides Enhance Neurogenesis, Cognitive Capacity, Muscle Function, and Body Composition in Older Adults: A Randomized, Triple-Blind, Controlled Clinical Trial
Dietary nucleotide supplementation enhances the benefits of spontaneous physical activity across all measured variables in older adults, highlighting nucleotides as promising nutritional support for healthy aging. YN exhibited a trend toward greater inflammatory modulation, whereas NF showed a tendency toward enhanced neurotrophic effects and functional improvements, with a statistically significant improvement in the Timed Up and Go Test (<i>p</i> = 0.014). These findings underscore the potential for tailored nucleotide-based interventions to optimize distinct physiological domains in aging populations.
Authors
- Pablo Jiménez‐Martínez (ORCID: https://orcid.org/0000-0003-2126-2416)
- Álvaro Juesas (ORCID: https://orcid.org/0000-0002-7538-4067)
- Javier Gené‐Morales (ORCID: https://orcid.org/0000-0002-5901-5245)
- Juan C. Colado (ORCID: https://orcid.org/0000-0002-3255-3940)
- Julio Fernández Garrido (ORCID: https://orcid.org/0000-0001-5195-5227)
- Eduard Romero Martín
- Óscar Caballero (ORCID: https://orcid.org/0000-0003-0396-7199)
- Ángel Saez-Berlanga (ORCID: https://orcid.org/0000-0002-8832-5250)
- Fernando Martín (ORCID: https://orcid.org/0000-0003-1996-8276)
- Carlos Alix‐Fages (ORCID: https://orcid.org/0000-0001-5135-7913)
- Iván Chulvi‐Medrano (ORCID: https://orcid.org/0000-0002-6612-1759)
- Agustín Jerez‐Martínez (ORCID: https://orcid.org/0009-0005-7486-2767)
- Pedro Gargallo (ORCID: https://orcid.org/0000-0003-2088-5224)
- Luis Garrigues-Pelufo
- Brayan S. Sandoval-Camargo (ORCID: https://orcid.org/0009-0007-9673-594X)
Institutions
- Universitat de València (ES)
- Universidad Cardenal Herrera CEU (ES)
- Universidad Católica de Murcia (ES)
- Universidad de Murcia (ES)
Publication Details
- Journal
- Nutrients
- Published
- 2025-04-24
- DOI
- https://doi.org/10.3390/nu17091431
- Citations
- 2
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 3.34
Funders
- Generalitat Valenciana