Anti‐Tumour Immunity Relies on Targeting Tissue Homeostasis Through Monocyte‐Driven Responses Rather Than Direct Tumour Cytotoxicity
These findings reveal the dual roles of similar pathways, where immune patterns targeting different cells shape distinct outcomes. Restoring tissue homeostasis and regeneration creates a tumour-hostile microenvironment, whereas tumour-directed approaches fail to remodel the TME. This underscores the need for tissue remodelling strategies in cancer prevention and treatment.
Authors
- Amy L. Olex (ORCID: https://orcid.org/0000-0001-8064-521X)
- Mulugeta Seneshaw (ORCID: https://orcid.org/0000-0003-4371-759X)
- Michael O. Idowu (ORCID: https://orcid.org/0000-0002-7416-5444)
- Masoud H. Manjili (ORCID: https://orcid.org/0000-0001-7511-2953)
- Hussein F. Aqbi (ORCID: https://orcid.org/0000-0002-8522-8084)
- Faridoddin Mirshahi (ORCID: https://orcid.org/0000-0002-4573-111X)
- Nicholas Koelsch (ORCID: https://orcid.org/0000-0002-6332-0007)
Institutions
- Mustansiriyah University (IQ)
- Virginia Commonwealth University (US)
- Virginia Cancer Institute (US)
- Children's Hospital of Richmond at VCU (US)
- VCU Massey Comprehensive Cancer Center (US)
- Virginia Commonwealth University Medical Center (US)
Publication Details
- Journal
- Liver International
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1111/liv.70110
- Citations
- 4
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- U.S. Department of Defense
- Georgia Clinical and Translational Science Alliance
- National Institutes of Health
- National Center for Advancing Translational Sciences