Structural and functional assessment of ganglion cell complex in patients on long-term hydroxychloroquine

Long-term HCQ use is associated with structural changes in the GCC, manifested as lower GC-IPL and RNFL thickness. Although there was a trend suggesting ganglion cell dysfunction (prolonged implicit times) and possible deficits in RNFL function (MD and PSD scores), statistically significant correlations could not be established with GC-IPL and RNFL thickness, respectively. GC-IPL/RNFL thickness assessment can be a part of the screening. Mere GC-IPL thickness reduction should not be a criterion to recommend HCQ cessation in the absence of abnormality on routinely recommended screening tests.