Repurposing of Furin Inhibitors to Reduce Pathogenic E. coli- and Shigella flexneri-Induced Cytotoxicity, Oxidative Stress and Inflammation in Mammalian Epithelial Cells
The development of new antimicrobial drugs that act via alternative mechanisms and effectively manage life-threatening enterobacterial infections is of key importance. Targeting furin with inhibitors MI-1851 and MI-2415, thus blocking toxin activation, could prevent the development of antimicrobial resistance, reduce the need for antibiotics and enhance overall treatment outcomes.
Authors
- András Adorján (ORCID: https://orcid.org/0000-0002-2555-6123)
- Annelie Wohlert
- Ákos Jerzsele (ORCID: https://orcid.org/0000-0002-3380-0827)
- Torsten Steinmetzer (ORCID: https://orcid.org/0000-0001-6523-4754)
- L Tóth (ORCID: https://orcid.org/0009-0008-7709-8268)
- Roman W. Lange (ORCID: https://orcid.org/0009-0004-7752-6403)
- Isabella Rumer
- Erzsébet Gere-Pászti
Institutions
- Philipps University of Marburg (DE)
- University of Veterinary Medicine (HU)
Publication Details
- Journal
- Antibiotics
- Published
- 2025-04-24
- DOI
- https://doi.org/10.3390/antibiotics14050431
- Primary Topic
- Escherichia coli research studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00