Sex and sex hormonal regulation of the atrial inward rectifier potassium current (IK1): insights into potential pro-arrhythmic mechanisms
Sex impacts on atrial electrophysiology, leading to sex-differences in P-wave morphology, triggered activity, RMP, and IK1. These sex-differences can be mimicked by sex hormone-treatment, suggesting that sex hormones-particularly DHT-play a pivotal role in mediating sex-differences in atrial electrophysiology. Such sex-differences might impact on the propensity to develop AF, particularly in the younger population.
Authors
- Ange Maguy
- András Horváth (ORCID: https://orcid.org/0000-0002-8974-0771)
- Julien Louradour (ORCID: https://orcid.org/0000-0002-0649-4975)
- Thomas Hof (ORCID: https://orcid.org/0000-0002-4386-5253)
- Ulrich Schotten (ORCID: https://orcid.org/0000-0003-1532-3315)
- Nicolò Alerni (ORCID: https://orcid.org/0000-0002-4929-3479)
- Miriam Barbieri (ORCID: https://orcid.org/0009-0002-4589-5998)
- Sahej Bains (ORCID: https://orcid.org/0000-0002-1357-7656)
- Giulio Conte (ORCID: https://orcid.org/0000-0003-2248-3456)
- Angelo Auricchio (ORCID: https://orcid.org/0000-0003-2116-6993)
- Saranda Nimani (ORCID: https://orcid.org/0000-0002-9298-3678)
- Katja E. Odening (ORCID: https://orcid.org/0000-0001-6999-841X)
- Rubén López (ORCID: https://orcid.org/0000-0002-3802-3158)
- Balázs Ördög (ORCID: https://orcid.org/0000-0002-8971-3079)
- Lucilla Giammarino (ORCID: https://orcid.org/0000-0002-2100-0160)
- Lluis Matas
- Varjany Vashanthakumar
Institutions
- University of Bern (CH)
- Heart Rhythm Society (US)
- Bern University of Applied Sciences (CH)
- Maastricht University Medical Centre (NL)
- University Hospital of Bern (CH)
- Maastricht University (NL)
- Ente Ospedaliero Cantonale (CH)
- Università della Svizzera italiana (CH)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1093/cvr/cvaf074
- Citations
- 8
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 11.11
Funders
- University of Bern
- European Commission
- Hartstichting
- Schweizerische Herzstiftung