Rapid Transmission and Divergence of Vancomycin-Resistant <i>Enterococcus faecium</i> Sequence Type 80, China
We investigated genomic evolution of vancomycin-resistant Enterococcus faecium (VREF) during an outbreak in Shenzhen, China. Whole-genome sequencing revealed 2 sequence type 80 VREF subpopulations diverging through insertion sequence-mediated recombination. One subpopulation acquired more antimicrobial resistance and carbohydrate metabolism genes. Persistent VREF transmission underscores the need for genomic surveillance to curb spread.
Authors
- Hongmei Mo
- Dayong Gu (ORCID: https://orcid.org/0000-0002-9547-8474)
- Yanyu Xiao (ORCID: https://orcid.org/0000-0002-5871-4159)
- Shucai Yang (ORCID: https://orcid.org/0000-0002-9694-828X)
- Yanpeng Zhang (ORCID: https://orcid.org/0000-0003-3827-8983)
- Jiuxin Qu (ORCID: https://orcid.org/0000-0003-1061-2353)
- Dixian Luo (ORCID: https://orcid.org/0000-0001-6155-8137)
- Jie Zhou (ORCID: https://orcid.org/0000-0002-7486-662X)
- Jiehong Wei (ORCID: https://orcid.org/0000-0001-6401-6747)
- Bing Fan (ORCID: https://orcid.org/0000-0001-8007-2036)
- Lianqing Li (ORCID: https://orcid.org/0000-0002-0022-1108)
- Zetian Lai (ORCID: https://orcid.org/0000-0003-0439-3959)
- Xingwei Wang (ORCID: https://orcid.org/0000-0003-2856-4716)
- Li Zhang (ORCID: https://orcid.org/0000-0002-5533-2577)
- Yidi Wang (ORCID: https://orcid.org/0009-0009-5556-8174)
Publication Details
- Journal
- Emerging infectious diseases
- Published
- 2025-04-24
- DOI
- https://doi.org/10.3201/eid3105.241649
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 0.00