Testicular and ovarian Juvenile granulosa cell tumors in children and adolescents: Analysis of 113 patients registered to the German Registry for Rare Pediatric Tumors (STEP)

Testicular and ovarian juvGCTs are clinically distinct entities. Although testicular juvGCTs exclusively present during infancy and have an excellent prognosis, ovarian juvGCTs may arise at any age and constitute potentially aggressive tumors. Centralized reference diagnostics and the establishment of counseling structures for the treatment of patients with ovarian juvGCTs improved prognosis compared with historical groups. The mitotic rate and incomplete surgery were identified as important risk factors in addition to tumor stage and should be considered in the risk-stratification of therapy.

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Publication Details

Journal
Cancer
Published
2025-04-24
DOI
https://doi.org/10.1002/cncr.35861
Primary Topic
Ovarian cancer diagnosis and treatment
Type
article
Field-Weighted Citation Impact
0.00

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article

Testicular and ovarian Juvenile granulosa cell tumors in children and adolescents: Analysis of 113 patients registered to the German Registry for Rare Pediatric Tumors (STEP)

Tabea Blessing, Martin Benesch, Gabriele Calaminus, Norbert M. Graf et al.
Cancer
Ovarian cancer diagnosis and treatment
article

Testicular and ovarian Juvenile granulosa cell tumors in children and adolescents: Analysis of 113 patients registered to the German Registry for Rare Pediatric Tumors (STEP)

Tabea Blessing, Martin Benesch, Gabriele Calaminus, Norbert M. Graf, Ines B. Brecht, Kris Ann P. Schultz, Andrea Witowski, Benedikt Bernbeck, Michael Abele, Christian Vokuhl, Dominik T. Schneider, U. Göbel, Bastian Brummel
article en

Abstract

Testicular and ovarian juvGCTs are clinically distinct entities. Although testicular juvGCTs exclusively present during infancy and have an excellent prognosis, ovarian juvGCTs may arise at any age and constitute potentially aggressive tumors. Centralized reference diagnostics and the establishment of counseling structures for the treatment of patients with ovarian juvGCTs improved prognosis compared with historical groups. The mitotic rate and incomplete surgery were identified as important risk factors in addition to tumor stage and should be considered in the risk-stratification of therapy.

CancerVol. 131(9)
University of Bonn (DE), Medical University of Graz (AT), University Hospital Bonn (DE), Center for Cancer and Blood Disorders (US), University Children's Hospital Tübingen (DE), Klinikum Dortmund (DE), Children's Minnesota (US), Heinrich Heine University Düsseldorf (DE), Saarland University (DE)
Deutsche Kinderkrebsstiftung, National Institutes of Health, National Cancer Institute
Good health and well-being
Openalex Percentile: Top 88%
Ovarian cancer diagnosis and treatment
DOIOpen Access PDFOpenAlex
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