SETD7 drives diabetic endothelial dysfunction through FBXO45-mediated GPX4 ubiquitylation
In summary, our study demonstrates that SETD7-p53-FBXO45-GPX4 is involved in high glucose-induced oxidative stress injury and exacerbated endothelial dysfunction, which offering great significance for mitigating hyperglycemia-induced endothelial damage.
Authors
- Feng Zhu (ORCID: https://orcid.org/0000-0002-9356-2154)
- Huibin Wang (ORCID: https://orcid.org/0000-0003-3765-1520)
- Chunxiang Fan
- Jialin Zhao (ORCID: https://orcid.org/0000-0001-6475-6673)
- Wen Zhong (ORCID: https://orcid.org/0000-0001-7623-5082)
- Xinhua Liu (ORCID: https://orcid.org/0000-0002-7797-6699)
- Yuyu Zhang (ORCID: https://orcid.org/0000-0003-3095-3083)
- Jintao He (ORCID: https://orcid.org/0000-0003-2083-657X)
- Ruoxue Chen
Institutions
- Pudong Medical Center (CN)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1186/s12933-025-02740-6
- Citations
- 7
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 9.23