Intranasal Midazolam Prior to Enema for Management of Constipation in the Pediatric Emergency Department

Intranasal midazolam prior to enema administration was not associated with an overall higher rate of successful bowel movement in the PED. Pre-school-aged children showed a small improvement in bowel movement success with midazolam. Midazolam administration was associated with worse secondary outcomes, but there are likely other confounding factors such as severity of illness. Intranasal midazolam may provide benefits to preschool-aged children, but a prospective study is needed to confirm this finding.