Type I interferon dysregulation drives distinct pathogenic pathways in early- and late-onset lupus nephritis

Early-onset LN is characterized by elevated type I IFN activity and neutrophil-driven inflammation, reflecting a more aggressive phenotype. These findings highlight the potential therapeutic targets and emphasize the importance of personalized treatment. Early modulation of type I IFN may prevent fibrosis and improve renal outcomes in early-onset LN.

Authors

Atsushi Kawakami (ORCID: https://orcid.org/0000-0001-9461-6372)
Hiroko Hagiwara
Kunihiro Ichinose (ORCID: https://orcid.org/0000-0001-8794-7106)
Mineaki Kitamura (ORCID: https://orcid.org/0000-0002-0003-8645)
Tomoya Nishino (ORCID: https://orcid.org/0000-0002-6270-3655)

Institutions

University of Nagasaki (JP)
Shimane University (JP)
Nagasaki University (JP)

Publication Details

Journal: Lara D. Veeken
Published: 2025-04-22
DOI: https://doi.org/10.1093/rheumatology/keaf211
Citations: 3
Primary Topic: Systemic Lupus Erythematosus Research
Type: article
Field-Weighted Citation Impact: 5.00

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article

Type I interferon dysregulation drives distinct pathogenic pathways in early- and late-onset lupus nephritis

Atsushi Kawakami, Hiroko Hagiwara, Kunihiro Ichinose, Mineaki Kitamura et al.

Apr 22, 2025

3 citations

Lara D. Veeken

Systemic Lupus Erythematosus Research

5.00

article

Type I interferon dysregulation drives distinct pathogenic pathways in early- and late-onset lupus nephritis

Atsushi Kawakami, Hiroko Hagiwara, Kunihiro Ichinose, Mineaki Kitamura, Tomoya Nishino

April 22, 2025article en

3 citations

Abstract

Early-onset LN is characterized by elevated type I IFN activity and neutrophil-driven inflammation, reflecting a more aggressive phenotype. These findings highlight the potential therapeutic targets and emphasize the importance of personalized treatment. Early modulation of type I IFN may prevent fibrosis and improve renal outcomes in early-onset LN.

Lara D. VeekenVol. 64(9)

University of Nagasaki (JP), Shimane University (JP), Nagasaki University (JP)

Good health and well-being

Openalex Percentile: Top 5%

Systemic Lupus Erythematosus Research

5.00

DOI Source OpenAlex

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