E2F expression profiling-based subtypes in head and neck squamous cell carcinoma: clinical relevance, prognostic implications, and personalized therapy
These findings reveal two distinct E2F-based molecular subtypes of HNSCC that differ in prognosis, functional pathways, immune infiltration, and drug sensitivity. The prognostic model offers valuable risk stratification and identifies potential biomarkers and therapeutic targets, warranting further experimental and clinical validation.
Authors
- Lijuan Zhou (ORCID: https://orcid.org/0000-0002-7720-4138)
- Huanyu Jiang
- Zhenkun Yu
- Haidong Zhang (ORCID: https://orcid.org/0000-0003-2972-8049)
Institutions
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Southeast University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- World Journal of Surgical Oncology
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1186/s12957-025-03808-z
- Citations
- 1
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.85