Longitudinal association of perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) exposure with lipid traits, in a healthy unselected population
PFAS remain persistent in the environment, despite regulations, due to their structural properties, leaving humans open to exposure. There is less understanding of how chronic low exposure to these chemicals, particularly within an unselected population, may impact health outcomes. This study reports the longitudinal associations of PFOA and PFOS over an 18-year window with 5 lipid phenotypes, highlighting that despite falling serum levels, PFAS exposure may lead to hyperlipidaemia. We further investigate the cross-sectional associations across three timepoints to understand time-dependent effects, demonstrating associations persist. This work aids our understanding on the long-term effect of chronic PFAS exposure.
Authors
- Kerrin S. Small (ORCID: https://orcid.org/0000-0003-4566-0005)
- Mario Falchi (ORCID: https://orcid.org/0000-0002-5646-1004)
- Claire J. Steves (ORCID: https://orcid.org/0000-0002-4910-0489)
- Ruth C. E. Bowyer (ORCID: https://orcid.org/0000-0002-6941-8160)
- Dongmeng Wang (ORCID: https://orcid.org/0000-0002-4178-9103)
- Yasrab Raza
- Max Tomlinson (ORCID: https://orcid.org/0000-0002-9136-543X)
- Julia S. El-Sayed Moustafa (ORCID: https://orcid.org/0000-0001-6963-6654)
- Cristina Menni (ORCID: https://orcid.org/0000-0001-9790-0571)
- Xinyuan Zhang (ORCID: https://orcid.org/0000-0003-3693-3374)
Institutions
- King's College London (GB)
- University of Milan (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
Publication Details
- Journal
- Journal of Exposure Science & Environmental Epidemiology
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1038/s41370-025-00773-3
- Citations
- 4
- Primary Topic
- Per- and polyfluoroalkyl substances research
- Type
- article
- Field-Weighted Citation Impact
- 3.44
Funders
- Wellcome Trust
- Dipartimenti di Eccellenza
- National Institute for Health and Care Research
- King's College London
- European Commission
- China Scholarship Council
- Versus Arthritis
- Medical Research Council