Functionalization of Implantable Systems for Controlled Drug Delivery and Beyond

Abstract The functionalization of implantable systems through polymer coatings offers a promising strategy to enhance the therapeutic performance and longevity of medical devices. These coatings serve as versatile platforms for delivering therapeutic agents directly at the site of implantation, addressing specific clinical needs while minimizing systemic side effects. This review examines key polymer coating techniques, including dip coating, spray coating, spin coating, and chemical vapor deposition, which enable precise control over coating thickness, composition, and drug release profiles. Such control allows for tailored therapeutic outcomes, optimizing the interaction between the implant and surrounding tissues. The functionalities provided by these coatings include biocompatibility, which ensures minimal immune response; anti-fouling properties that prevent unwanted protein and cell adhesion; and the reduction of corrosion, friction, and wear, which improves the durability of implants. A particular focus is placed on drug delivery and the controlled release of anti-inflammatory agents, which can significantly modulate local inflammation, reduce adverse immune responses, and promote better integration of the implant with host tissues. By exploring both the current challenges and future directions in the field, this review underscores the potential of polymer coatings to revolutionize implantable drug delivery systems, paving the way for more effective and safer therapeutic options. Lay Summary The development of medical implants requires research into material properties like biomechanics and biocompatibility to ensure effective function, seamless tissue integration, and reduced immune responses. As implants evolve, polymer coatings play a crucial role in enhancing performance and safety. This review explores how polymer coatings can enhance implant functionality by analyzing common synthesis methods and their intended functionality when applied to implantable devices. Additionally, it provides a thorough analysis of their use in delivering therapeutic agents, with a focus on managing foreign body reactions and recent advancements in releasing anti-inflammatory drugs to improve implant integration, functionality, and longevity.