Hypertensive disorders of pregnancy and neuroimaging markers of dementia risk: A pilot study
Midlife individuals who experienced HDP had lower regional CBF and reduced white matter microstructural integrity, compared with those with no adverse pregnancy outcomes. Our results suggest that HDP are associated with long-term impairment of white matter structure and cerebrovascular function, potentially suggesting a mechanism underlying the association of HDP with risk of cognitive decline, and requiring further study.
Authors
- Noora Haghighi
- Rupa Ravi (ORCID: https://orcid.org/0000-0002-2821-5535)
- Adam M. Brickman (ORCID: https://orcid.org/0000-0002-5125-8226)
- Becky McNeil
- Dejania Cotton‐Samuel (ORCID: https://orcid.org/0000-0003-0876-0701)
- Rafael V. Lippert
- Victoria L. Pemberton (ORCID: https://orcid.org/0000-0001-5610-9070)
- Victoria Solomon (ORCID: https://orcid.org/0009-0004-8565-7614)
- Yufen Chen (ORCID: https://orcid.org/0000-0001-8959-9571)
- Joseph Chiu (ORCID: https://orcid.org/0000-0002-9058-039X)
- Jeffrey D. Pyne
- Mohamad J. Alshikho
- Todd B. Parrish (ORCID: https://orcid.org/0000-0002-1184-1572)
- Elizabeth Rangel (ORCID: https://orcid.org/0000-0003-2156-5089)
- Kelsang C. Bista
- Lynn M. Yee (ORCID: https://orcid.org/0000-0002-6274-0544)
- Eliza C. Miller (ORCID: https://orcid.org/0000-0002-7108-8906)
- Uma M. Reddy (ORCID: https://orcid.org/0000-0002-8599-6040)
- Natalia Campos Vásquez
- Julia F. Chang
- Carla Haro
- Sheica Cedano
Institutions
- Northwestern University (US)
- National Institutes of Health (US)
- University of Pittsburgh (US)
- RTI International (US)
- McCormick (United States) (US)
- National Heart, Lung, and Blood Institute (US)
- Columbia University (US)
Publication Details
- Journal
- Pregnancy
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1002/pmf2.70020
- Citations
- 1
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 2.06
Funders
- National Institutes of Health
- National Institute on Aging
- National Heart, Lung, and Blood Institute