Prominence of Mycobacterium tuberculosis biomarkers among sputum culture-negative clinic attendees, independent of Ultra status
TB bacterial and host biomarkers were prevalent and no different between sputum-discordant and sputum-negative participants, raising concern for a considerable population of undiagnosed culture-negative TB. These findings parallel new evidence of Mtb aerosolization from sputum-negative individuals and highlight a need for more comprehensive diagnostics that detect sputum culture-negative TB with respect to infectiousness, pathology, and risk of progression.
Authors
- Judi van Heerden
- Yingda L. Xie (ORCID: https://orcid.org/0000-0001-5587-4731)
- Christie Eichberg (ORCID: https://orcid.org/0000-0002-6501-6295)
- Padmini Salgame (ORCID: https://orcid.org/0000-0003-2245-3767)
- Elizabeth Nakabugo
- Vaishnavi Kaipilyawar (ORCID: https://orcid.org/0000-0002-8940-8509)
- Kimberly D. McCarthy
- Robert Reiss (ORCID: https://orcid.org/0000-0002-1131-0907)
- Samuel Kennedy (ORCID: https://orcid.org/0000-0001-8088-6339)
- Ronald Odero
- Nchimunya Hapeela
- Chad M. Centner (ORCID: https://orcid.org/0000-0001-7289-534X)
- Kattya Lopez
- Widaad Zemanay
- Padmapriya P. Banada (ORCID: https://orcid.org/0000-0002-5217-6142)
- Irene Anyango
- Kiranjot Arora
- David Alland (ORCID: https://orcid.org/0000-0001-5196-1571)
- Moses Lutaakome Joloba (ORCID: https://orcid.org/0000-0002-0334-9983)
- Nisha Modi (ORCID: https://orcid.org/0000-0002-8332-6078)
- Jorge Robledo
- Jerrold J. Ellner (ORCID: https://orcid.org/0000-0001-6150-0082)
- Lydia Nakiyingi (ORCID: https://orcid.org/0000-0001-7263-3198)
- Susan E. Dorman (ORCID: https://orcid.org/0000-0001-6882-9470)
Institutions
- Rutgers, The State University of New Jersey (US)
- Medical University of South Carolina (US)
- University of Cape Town (ZA)
- Kenya Medical Research Institute (KE)
- Infectious Diseases Institute (UG)
- Centers for Disease Control and Prevention (KE)
- Makerere University (UG)
Publication Details
- Journal
- Journal of Infection and Public Health
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1016/j.jiph.2025.102791
- Citations
- 2
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases
- Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases