Transcriptomic signatures in response to antioxidants supplementation in Korean cattle beef, Hanwoo: a 7-month feeding study
While no significant differences were observed in phenotypic traits such as weight gain and feed conversion ratio, transcriptomic analysis identified 641 differentially expressed genes between the CON and FEED groups. Functional enrichment analysis revealed that differentially expressed genes were mainly associated with transcription regulation, pseudouridine synthesis, and mitochondrial function. These findings suggest that antioxidant supplementation elicits significant molecular changes in the liver, particularly affecting transcriptional activity and mitochondrial processes, even in the absence of detectable phenotypic differences.
Authors
- Hyung Taek Cho
- Eui‐Cheol Shin (ORCID: https://orcid.org/0000-0003-4243-4643)
- Jae Kyeom Kim (ORCID: https://orcid.org/0000-0002-2837-9302)
- Soo‐Jin Yeom (ORCID: https://orcid.org/0000-0001-7307-237X)
- Jaeyong Song (ORCID: https://orcid.org/0000-0002-8613-5605)
- Jiangchao Zhao (ORCID: https://orcid.org/0000-0002-2894-8560)
- Leena Choi (ORCID: https://orcid.org/0000-0002-2544-7090)
- Jae-Soon Shin
- Hyo Ri Shin (ORCID: https://orcid.org/0000-0003-4161-4271)
- Tae Jin Cho
- Nam Su Oh (ORCID: https://orcid.org/0000-0002-0712-7843)
- Kangwook Lee (ORCID: https://orcid.org/0000-0002-9455-0163)
- Jun Sang Ahn (ORCID: https://orcid.org/0000-0001-7362-9270)
- Joong Kook Park (ORCID: https://orcid.org/0000-0002-9959-0578)
- Young Jun Kim (ORCID: https://orcid.org/0000-0002-7991-8599)
- Tae‐Gyun Kim (ORCID: https://orcid.org/0000-0002-2116-4579)
- Dahye Kim (ORCID: https://orcid.org/0000-0002-2241-3960)
- Suin Yun
- Jeong Heon Lee
Institutions
- Chonnam National University (KR)
- Gyeongsang National University (KR)
- Korea University (KR)
- Soonchunhyang University (KR)
- Rural Development Administration (KR)
- Department of Behavioral Health (US)
- Far East University (KR)
- Gwangmyeong Mental Health Welfare Center (KR)
- National Institute of Animal Science (KR)
- University of Arkansas at Fayetteville (US)
Publication Details
- Journal
- Frontiers in Veterinary Science
- Published
- 2025-04-24
- DOI
- https://doi.org/10.3389/fvets.2025.1546248
- Citations
- 1
- Primary Topic
- Molecular Biology Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Ministry of Food and Drug Safety