Proteolytic signatures of coagulation identified by plasma peptidomics
Plasma peptidomics of coagulation-initiated limited proteolysis captures peptide products derived from pro- and anticoagulant events and proteolytic signatures beyond the classical coagulation system. We envision that this peptidomics strategy enables the assessment of functional aspects of coagulation in bleeding and thrombotic disorders at the molecular level.
Authors
- Floris P. J. van Alphen
- Herm Jan M. Brinkman (ORCID: https://orcid.org/0000-0002-0264-1528)
- Tirsa T van Duijl
- Joost C.M. Meijers (ORCID: https://orcid.org/0000-0002-4198-6780)
- Alexander B. Meijer (ORCID: https://orcid.org/0000-0002-5447-7838)
- Jessica Del Castillo Alferez
- Maartje van den Biggelaar
- Carmen van der Zwaan
- Alette Kooiker
Institutions
- Sanquin (NL)
- Amsterdam University Medical Centers (NL)
Publication Details
- Journal
- Journal of Thrombosis and Haemostasis
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1016/j.jtha.2025.04.017
- Citations
- 2
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.54
Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek