Dessicating stress triggers and exacerbates experimental ocular Graft-versus-host-disease
The data presented strengthens the hypothesis, that desiccating stress during aHSCT is a risk factor for oGVHD. Together with already published clinical data, there is increasing evidence that implicates protecting patients from desiccation during the engraftment of allogeneic hematopoietic stem cells. Furthermore, specific prophylactic therapies should be developed and tested to reduce the incidence and severity of oGVHD.
Authors
- Daniela Stary
- Uta Gehlsen (ORCID: https://orcid.org/0000-0001-9057-9199)
- Martina Maaß
- Philipp Steven (ORCID: https://orcid.org/0000-0001-6892-3619)
- Svenja Wagener‐Ryczek (ORCID: https://orcid.org/0000-0002-2870-5606)
- Cintia S. de Paiva (ORCID: https://orcid.org/0000-0002-9057-5494)
- Gwen Musial (ORCID: https://orcid.org/0000-0003-4143-2902)
- Manolis Pasparakis (ORCID: https://orcid.org/0000-0002-9870-0966)
- Michael E. Stern
Institutions
- University of Cologne (DE)
- Baylor College of Medicine (US)
- Integrated Oncology (United States) (US)
- Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (DE)
- University Hospital Cologne (DE)
Publication Details
- Journal
- The Ocular Surface
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1016/j.jtos.2025.04.008
- Primary Topic
- Corneal Surgery and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Research to Prevent Blindness
- Deutsche Forschungsgemeinschaft