Length of ischemia duration is associated with fibrin film coverage of acute myocardial infarction thrombi
These findings show that fibrin film is an integral structural feature that covers around one-quarter of the surface of all coronary thrombi and that older thrombi contain more film. This new structure on thrombi may have important implications for clot contraction, resistance to thrombolysis, and mechanical clot extraction.
Authors
- John Pierre Greenwood (ORCID: https://orcid.org/0000-0002-2861-0914)
- Dana Huskens (ORCID: https://orcid.org/0000-0002-5999-5685)
- Robert As Ariëns
- Ilaria De Simone (ORCID: https://orcid.org/0000-0003-1037-8456)
- Helen R. McPherson (ORCID: https://orcid.org/0000-0002-3519-498X)
- Cédric Duval (ORCID: https://orcid.org/0000-0002-4870-6542)
- Bas de Laat
Institutions
- University of Leeds (GB)
- Baker Heart and Diabetes Institute (AU)
- Synapse (Netherlands) (NL)
- Monash University (AU)
Publication Details
- Journal
- Journal of Thrombosis and Haemostasis
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1016/j.jtha.2025.04.016
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- British Heart Foundation
- Leeds Biomedical Research Centre